Tesamorelin – 10 mg | For Research Use Only – Not for Human Consumption

Tesamorelin is a synthetic peptidyl analog of growth hormone-releasing hormone (GHRH 1–44), engineered to resist degradation by dipeptidyl peptidase IV (DPP-IV) and extend its biological half-life. This stabilized GHRH analog selectively binds to GHRH receptors on pituitary somatotrophs, inducing endogenous pulsatile growth hormone (GH) secretion and subsequently elevating insulin-like growth factor-1 (IGF-1) levels.

Mechanistic Overview

Tesamorelin activates the hypothalamic-pituitary-somatotropic axis, enhancing GH release and downstream IGF-1 production, both of which regulate lipid metabolism, protein synthesis, and neuronal support functions. Its enhanced pharmacokinetics and receptor specificity make it a powerful tool for evaluating GH-mediated physiological and metabolic responses in research models.

Preclinical and experimental studies have shown Tesamorelin to:

• Stimulate lipolysis and reduce visceral adipose tissue accumulation

• Improve glucose and lipid metabolic parameters

• Enhance peripheral nerve integrity and myelin repair mechanisms

• Modulate neuronal plasticity and cognitive function through IGF-1–related pathways

• Exhibit neuroprotective effects in models of age-related cognitive decline

Research Applications

Tesamorelin is studied in in vitro and in vivo models for its potential in:

• GH deficiency and metabolic syndrome research

• Visceral adiposity and lipodystrophy models

• Peripheral neuropathy and neuroregeneration

• Cognitive aging and neurodegenerative disease pathways

• GH/IGF-1 axis modulation in systemic aging models

Its dual relevance in metabolic regulation and neuroendocrine health positions Tesamorelin as a valuable investigational compound in regenerative and therapeutic peptide research.

Product Specifications

• Peptide Content: 2 mg (lyophilized)

• Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Gly-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂

• Purity: >98% (validated by HPLC & MS)

• Storage: Store lyophilized at –20°C; reconstituted solution should be refrigerated at 2–8°C